Acute GVH disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Incidence of aGVHD and cGVHD was higher in 2 HLA-A locus donor/recipient groups (02: 01/02: 06 and 02: 01/02: 07; p≤0.022). aGVHD incidence was associated with patient age, absence of rabbit anti-thymocyte globulin (ATG) pretreatment, and disease status (p≤0.040). aGVHD appeared to be a risk factor for cGVHD, and total body irradiation (TBI) was also associated with cGVHD.
|
28652564 |
2017 |
Acute GVH disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
A case-control design (grade III-IV versus no acute GvHD) and pooled GWA approach was used to study European-American recipients with hematological malignancies who received myeloablative conditioning non-T-cell-depleted first transplantation from HLA-A, -B, -C, -DRB1, -DQB1 allele level (10/10) matched unrelated donors.
|
27595289 |
2017 |
Acute GVH disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We studied the independent impact of amino acid substitution (AAS) at peptide-binding positions 9, 99, 116, and 156, and killer immunoglobulin-like receptor binding position 77 of HLA-A, B, or C, on the risks for grade 3-4 acute graft-versus-host disease (GVHD), chronic GVHD, treatment-related mortality (TRM), relapse, and overall survival.
|
23982174 |
2013 |
Acute GVH disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Only substitution at residue 9 resulting from an HLA-A*02 polymorphism was significantly associated with the risk of severe acute GVHD in patients (OR=7.0, P=0.033) on multivariate analysis.
|
20536911 |
2010 |
Acute GVH disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The risk of acute graft-versus-host disease (GVHD) of these HLA haplotypes was assessed with multivariate Cox regression in 712 patients transplanted from HLA fully (HLA-A, B, C, DRB1, DQB1, and DPB1) matched unrelated donors.
|
20335219 |
2010 |
Acute GVH disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Phase II study of tacrolimus and methotrexate for prophylaxis of acute graft-versus-host disease after HLA-A, B, and DRB1 genotypically mismatched unrelated bone marrow transplantation among Japanese patients.
|
19052693 |
2009 |
Acute GVH disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, we report for the first time that a 30-year-old female acute monocytic leukemia patient with an HLA-A/B recombinant haplotype, who has three unmatched and one HLA-B/DRB1 recombinant haplotype siblings, presented grade IV acute GVHD (aGVHD) after transplantation from a sibling with a single allele only mismatch at the classical HLA-A locus.
|
17990988 |
2007 |
Acute GVH disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
There was no significant association between number of MM (HR) for both HLA-A, -B and -DRB1 and HLA-A, -B, -C, -DRB1 and DQB1 and aGvHD grade II-IV.
|
16247425 |
2005 |
Acute GVH disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order to evaluate the impact of HLA-DBP1 incompatibilities on the occurrence of acute graft-versus-host disease (GVHD) in unrelated hematopoietic cell transplantation, we studied 57 donor/recipient pairs characterized by their allelic identity for HLA-A, B, C, DRB1 and DQB1 and also for DRB3, 4, 5 loci and aimed to correlate DPB1 mismatches to already described risk factors for GVHD using multivariate Cox regression analysis.
|
12379888 |
2002 |
Acute GVH disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For patients who underwent transplantation in the first chronic phase (CP) from HLA-A, B matched donors, the presence of DRB1 allele mismatching was independently associated with increased incidence of grades III-IV acute graft-versus-host disease (GVHD).
|
11698272 |
2001 |
Acute GVH disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude, that HLA-identical siblings can be identified by means of serological typing for HLA-A and B and intermediate resolution molecular typing for DRB and DQB, but that for the prediction of aGVHD cellular tests with higher sensitivity and specificity as compared to the currently used HTLp-f and CTLp-f assays need to be developed.
|
9877266 |
1998 |
Acute GVH disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Multivariate analysis showed that incompatibility for HLA-A alleles and incompatibility for HLA-C alleles were independent risk factors for severe acute graft-versus-host disease (GVHD) (HLA-A, P=0.006; HLA-C, P=0.001).
|
9780337 |
1998 |
Acute GVH disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We studied 129 patients who underwent marrow transplantation from HLA-A, -B, -DRB, and -DQB matched URDs to determine whether matching for HLA-DPB1 alleles significantly decreased the risk of developing acute GVHD.
|
8461476 |
1993 |
Acute GVH disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The utility of the MLC assay as a test of HLA-D region matching and predictor of acute graft-versus-host disease (GvHD) was evaluated in 157 patients receiving marrow grafts from HLA-A, B identical related haploidentical donors.
|
7817382 |
1994 |
Acute GVH disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study we have compared CTL-p frequencies with clinical GVHD, and demonstrate for the first time a significant correlation (P less than 0.005) between high CTL precursor frequency prior to BMT and severity of acute GVHD after HLA A, B, DR "matched" unrelated donor transplants using T cell depleted marrow.
|
2508280 |
1989 |